August 2007 Archives

August 8, 2007

High-choline diet linked to colorectal polyps in women

filed under: Choline Risks
A new research study covered by Reuters suggests that a high choline diet may be linked to increased risk of developing colorectal polyps in women. Obviously, any negative side effects of taking choline need to be thoroughly researched and understood.  The Reuter's write up notes:

"Because dietary choline is a methyl-group donor, as is folate, the investigators suspected it would have folate's anti-cancer characteristics."

Dr. Cho's group hypothesizes that "once a tumor is initiated, growth into a detectable adenoma depends in part on choline availability because choline is needed to make membranes in all rapidly growing cells."

The editorialists, from the National Cancer Institute in Bethesda, Maryland, urge "caution in developing public health policy" until more data are available. "We should remember the surprises and complexities that emerged for beta-carotene, vitamin E, vitamin C, and selenium, other initially promising chemopreventive agents."

Read the full story here: High-choline diet linked to colorectal polyps in women

Journal Research source: J Natl Cancer Inst 2007;99:1214-1215,1224-1231.