Recently in Choline Benefits Category

September 5, 2012

Update on Second Child - Personal experience with Choline

filed under: Choline Benefits Personal Experience
We've been having great luck with getting our second child to eat the 1 gram+ per day of choline (in the form of Lecithin granules) added to pancake mix, on a near daily basis.  So I'd really recommend people try this approach if they are having problems in this area (which we did for a long time). 

I buy whole wheat pancake mix from Trader Joes, add crushed walnuts, and miscellaneous other things I find around the kitchen (extra egg yolks, oat bran, flax, chia seeds, etc.) and a large amount of choline - that works out to about a gram of choline per pancake.  I also add a lot of cinnamon powder, and vanilla extract - and you can hardly taste the choline when the pancakes are finished.  Add a little low-sugar jam, etc. - and the kids love them.

Our second child is doing well, and recently passed the 24 month/ 2-year milestone.  She is very conversationally fluent - I haven't counted the words - but perhaps in the range of 500 to 1,000 words in English, and perhaps half that in Chinese/Mandarin.  She counts to 10 without a problem, and knows the alphabet (to say it, but not to identify the letters, which we haven't worked on at all.

Friends have commented both on the advanced verbal skills (talks a lot, in sentences), and on the advanced motor skills (runs, climbs and moves quickly and accurately) of our second child.  Choline seems to be working well, and we are following an ongoing diet of 1 gram per day for children.
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July 31, 2012

Pregnancy, Stress, Choline and Epigenetics - Later Life Stress and Anxiety

filed under: Choline Benefits Prenatal Choline Research Study

New research suggests that choline supplementation in pregnant women lowers cortisol in the baby by changing epigenetic expression of genes involved in cortisol production.

If you're sick from stress, a new research report appearing in the August 2012 issue of The FASEB Journal suggests that what your mother ate -- or didn't eat -- may be part of the cause. The report shows that choline intake that is higher than what is generally recommended during pregnancy may improve how a child responds to stress. These improvements are the result of epigenetic changes that ultimately lead to lower cortisol levels. Epigenetic changes affect how a gene functions, even if the gene itself is not changed. Lowering cortisol is important as high levels of cortisol are linked to a wide range of problems ranging from mental health to metabolic and cardiovascular disorders.

"We hope that our data will inform the development of choline intake recommendations for pregnant women that ensure optimal fetal development and reduce the risk of stress-related diseases throughout the life of the child," said Marie A. Caudill, Ph.D., a researcher involved in the work from the Division of Nutritional Sciences and Genomics at Cornell University in Ithaca, New York.

To make this discovery, Caudill and colleagues conducted a 12-week study involving pregnant women in their third trimester who consumed either the control diet providing 480 mg choline per day, a level that approximates current dietary recommendations, or the treatment diet which provided 930 mg choline per day. Maternal blood, cord blood and placenta tissue were collected to measure the blood levels of cortisol, the expression levels of genes that regulate cortisol, and the number of methyl groups attached to the DNA of the cortisol regulating genes (the epigenetic changes). Those from mothers who consumed the higher levels of choline showed reduced levels of cortisol.

"Depending on the relationship, one's mother can either produce stress or relieve it," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report shows that her effect on stress begins even before birth. The importance of choline cannot be overstated as we continue to unravel the role it plays in human health and development."

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July 31, 2012

The Right Vitamin Supplementation might lead to "Super Baby"

filed under: Choline Benefits
An interesting news article on CBS News - it seems that the world is slowly starting to wake up to the opportunities here:

"It is possible that eating more omega-3 fatty acids, choline, betaine, folic acid and vitamin B12, by mothers and fathers, possibly can alter chromatin state and mutations, as well as have beneficial effects...leading to birth of a 'super baby' with long life and [lower risk] of diabetes and metabolic syndrome," Singh told LiveScience. "This is just a possibility, to be proven by more experiments." 

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May 2, 2012

New Study: Choline Programs Healthier, Low Stress Babies

filed under: Choline Benefits Prenatal Choline Research Study
The following new research news is an interesting example of research that has been hinted at for many years now.  I spoke with a Choline researcher down at the University of Southern California back in 2008 and he said that in their (unpublished work) when they stress female mice during pregnancy over generations that they start finding the same brain changes in the offspring that are indicative of autism and schizophrenia in humans.  When they then fed high rates of choline to the same batches of female mice - the offspring showed none of these changes.  

I think we'll see a lot more research in this area moving forward - if we see that choline can in fact greatly reduce the rates of mental illness in children - as it currently seems.  During the past 5 years much more has become known about the role that prenatal stress (eg. cortisol and glucocorticoids) plays in the risk of mental illness (that is, a very important roll in mental illness) - and this new research below really suggests that most cases of mental illness may be prevented if women had higher choline intakes during pregnancy.  This is very, very exciting work.  

Public release date: 2-May-2012

Source: Cornell University 


Pioneering study shows prenatal choline may 'program' healthier babies

ITHACA, N.Y. - Pregnant women may have added incentive to bulk up on broccoli and eggs now that a Cornell University study has found increased maternal intake of the nutrient choline could decrease their children's chances of developing hypertension and diabetes later in life.

In a study led by Marie Caudill, associate professor of nutritional sciences, and graduate student Xinyin Jiang, a group of third-trimester pregnant women consumed 930 milligrams of choline, more than double the recommended 450 milligram daily intake. The result for their babies was 33 percent lower concentrations of cortisol - a hormone produced in response to stress that also increases blood sugar - compared to those from a control group of women who consumed about 480 milligrams of choline.

Caudill believes this happened because the choline changed the expression patterns of genes involved in cortisol production. The work, published online this week in The Journal of the Federation of American Societies for Experimental Biology, is the first human study to suggest a role for choline in the "programming" of key biological processes in the baby.

"The study findings raise the exciting possibility that a higher maternal choline intake may counter some of the adverse effects of prenatal stress on behavioral, neuroendocrine and metabolic development in the offspring," Caudill said.

This could be especially useful for women experiencing anxiety and depression during their pregnancy, as well as conditions such as pre-eclampsia.

"A dampening of the baby's response to stress as a result of mom consuming extra choline during pregnancy would be expected to reduce the risk of stress-related diseases such as hypertension and type 2 diabetes throughout the life of the child," she added.

She said additional studies are needed to confirm the study findings and further explore long-term effects. Dietary sources of choline include egg yolks, beef, pork, chicken, milk, legumes and some vegetables. Most prenatal vitamin supplements do not include choline.

"We hope that our data will inform the development of choline intake recommendations for pregnant women that ensure optimal fetal development and reduce the risk of stress-related diseases," Caudill said. 

Here is the full research paper (click to on the link below to download and view):

Maternal choline intake alters the epigenetic stateof fetal cortisol-regulating genes in humans

Jiang2012_cholinecortisol.pdf



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May 2, 2012

Prenatal Choline Supplementation Video

filed under: Choline Benefits Prenatal Choline Research Study
I just found out that Cornell University has a video on prenatal choline  supplementation (supplementation during pregnancy) :

More choline for moms-to-be may improve kids' cognition

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