Choline Researcher Zeisel Suggests 850mg the minimum dose during Pregnancy

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At a talk at the Oregon Health Sciences University in May, 2007 - one of the top researchers who is focused on Choline ( Dr. Steven Zeisel , University of North Carolina) spoke.

" Dr. Zeisel pointed out that choline is very important for the fetal brain, and can be obtained as a supplement as phosphatidyl choline [obtained via Lecithin]. 2-4 eggs per day provide enough choline during pregnancy. The current daily value is 450 mg, but it would be useful to set the level at 850 mg. It is like fish oil, having lifelong effect on an infant's early brain development. "
There is an ongoing human study on choline in babies right now - where they are using 900mg doses (in the pregnant mothers). The US Food and Nutrition Board, Institute of Medicine in 1998 came out with a report on choline that suggested the maximum tolerable limit for adults (including pregnant women) is 3.75 grams/day (which is 50% of the level (7 grams/ day) at which researchers had seen any possible negative symptoms in studies.

People I have shared this information with have supplemented their diet (during pregnancy) with between 500mg and 4 grams per day, without any obvious negative symptoms - but the children are still young. One of the biggest risk factors in this is the quality of the supplements that people take and the risk of possible contamination of the supplements. Because of this - the researchers I've talked to tend to recommend eggs as the best source of choline (though one researcher recommended high quality Lecithin as a good source).

Source: (
Linus Pauling Institute meeting, May 2007) Medical Doctor's Research

You can read more about Choline here at the Linus Pauling Institute web site - Choline details